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What you want to watch out for are races that qualify with negative points (0 points isn't too big a problem, with care). That can put some combos of race/class in the hole for several levels.
It is possible to play with any mix of race and class. But some really aren't suited to the job, and make things more difficult. A first-time player is usually better off going with less esoteric mixes. Then once you know the game, you can begin fooling around with that lizard bishop and such.
Nightowl2
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