Turn Undead Level 18 is enough to kill Liches, except of course certain special Liches. I don't know about Vampires, but it should be in the area of Level 18.
The trick with Turning Undead is to stay moving so they can't hit you--but also keep them within the Turn Undead radius, which is something like 15 feet.
My juiciest kill was in Watcher's Keep -- SMALL ToB SPOILER
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One of the colors of the Globe Machine generates Undead. So, all I had to do was leave Turn Undead on (My Undead Hunter & Aerie) for a slaughterfest. The best one was 4 Devil Shades, who exploded simultaneously, and when you kill a Devil Shade, it spawns 2 Shadow Fiends, who of course explode 1 second later. Wheeeeee!
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Volothamp's Comeuppance
Everything you ever needed to know about the entire Baldur's Gate series......except spoilers.
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