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SPOILERS...
The quest for the Sirens' cave is "offered" to you by a NPC located in a region close to the area where you can find both the lighthouse and the cave in quaestion. It does not depend on your reputation. But you can visit the cave even if you do not accept the NPC (and quest) in your party.
South of the lighthouse you will find a mother who you is desperatly in need of help... I hope that helps.
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