They work against the Stealth skills, and Spot also helps you detect a pickpocket attempt on your person. Beyond that the skills only have as much use as module designers (and the players) give it.
It is not unheard of to have to roll a Spot or Listen check when you're out on a DMed quest for example, where good rolls give you a better idea of where the plot is going, help you find the better solution to a problem, or even provide that one final oppertunity to escape certain death. But for the most part, no, they're not the true must-have skills.
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