There are definitely compatibility issues with the modules. Check the last update for the mod carefully, and see what version of NWN it was LAST updated for. If that version predates one of the expansions the chances are good that you will run into compatibility issues.
In the same vein, the Planar Tear modules are at least one set of modules that I know from experience has issues when running under either v1.6.1 or v1.6.2. Attempting save games (at least in mplayer mode) will not only cause the game to crash to desktop, but also require that you reinstall NWN before it will run again!
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