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Sure - humanoid spellcasters can be disrupted from casting with a succesfull knockdown. However in the same time it takes to achieve a knockdown you can usually kill that spellcaster simply by hiting it repeatedly (and if you have a high number of attacks you will usually disrupt their spells b4 they ever cast a single spell). (Spellcasters typically run low on hitpoints, the ones that are easy to kill quickly, and the ones that don't usually are either immune to knockdown or are practically immune to knockdown.)
If your fighting melee style the key to just about all encounters is: hit hard (high damage), hit a lot (many attacks), always make contact (high hit probability).
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