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1. Yes you can! Fists, daggers, maces, halberds, it makes no difference.
2. Again, yes. And the same is true for the (SoU) expertise feats. It is useful for when you want that extra damage, without making it too hard to hit your foes. Improved power attack, on the other hand, will certainly come in handy when there is a lock or door in need of bashing.
3. Yes, you'll get the plague, but no, I don't think it's scripted. It is probably assumed that it takes a while for the plague to affect the body, or at least the body of a true adventurer such as yourself. Just long enough to find a cure...
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