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I don't think the alignment of the henchmen really affects the game, as long as you can deal with their unsettling nature. Both Tomi and Grimgnaw are fairly evil, but there's no reason not to use them.
It's not a bad idea to do all the quests for the henchman. Each one of them gives you an item and some of them are pretty good. One of them gives you a ring of regeneration, and there are no others available until chapter 2.
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