I have read posts by players who have had the key you get from Andrianna work opening the door in the study and I've read posts from players where it wouldn't work. One of the game oddities.
As I said, there are some worthwhile items in the chest but there is nothing game stopping. You can skip it or go back to Brimloch Roon and pick up some level 5 lockpicks. Hope that helps!
Wyv
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