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Did you make sure that you selected the person who was assigned the quest from Onabe, and that (s)he gave the potion to Mekdawa? Mekdwaw may rabbit on about the toad problem, but he should still accept the potion and acknowledge the delivery and so if you go back to Onabe, you should get the credit.
It is unlikely (but possible) that Mekdawa's inventory is full and so you cannot give him the potion. If this were the case, then you have to pickpocket something from him to free up some inventory space.
ps: When you mentioned that you solved the toad's problems, did you get the quest from Shinwiki, removed Scabban's evil and got Shinwiki's spear? If you have, then Mekdawa won't keep badgering you about the toads.
pps: If the toads really get on your nerve, ignore or toast them. You can still complete the game!
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