Hi!
Another way to deliver the potion to M is to run or ride past him, and then wait for him. When he gets close, try to give the potion to him.
If he's pissed, you'll have to reload the game. It might also be that attacking Mekdawa could turn the entire Toad Village hostile towards you (but I'm not sure on that one). If you want to make sure that you don't hit NPCs by mistake, change the game-playing mode to safe or guarded.
Cheers // Jazzid
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