Ziggy! Check out the Best Tips thread, and/or do a search on whatever creature or NPC or encounter or whatever you want to learn about. It's like WAY COOL, dude!
I killed the Vamp, Madda Mabig, right through the door! Yep, you can sometimes target something(or someONE)right through "solid" objects! I hadn't figured out how to open the door, and there she WAS.....until she no LONGER was!
+Dr.Pick