Lots of Lubrication, and don't forget the cheesedip.
If all else fails, run around your room screaming about ghosts until family/friends start a W&W intervention to prevent the onset of insanity.
Like most games, Blunt weapons are extra effective against walking dead, fire is good as well. It took me 20 times to kill the vampire nest, mainly for the fun of it since it was not required to solve the map.
And don't forget to collect skulls, it's always nice to collect skulls, even if you never plan to go back to the first town ever again, it's great to say "Look world! I'm carring 100+ human skulls!"
