The current consensus is that Bradley won't stop developing RPGs (if he can find the cash to do so). I have no information about whether it will be for the PC again, nor if it might be an online only game. (Don't think he should do that, but markets outside the single player PC games are more interesting to the publishers currently.)
It might be nice if it were a sequel of W&W, but I expect a new game to be nice too; W&W is a 'new' game, but still looks quite a lot like Wizardry.