I'll presume that you've tried talking to her and that she just won't talk back.
Even when you give her the scroll - you're going to end up killing her and the rest because the scroll will not do what they hoped it would do. Her offer is to either make you a vampire (I don't recommend it) or give you the key. Near as anyone has discovered this key doesn't actually open anything that you cannot open another way.
My recommendation would be just to kill her and her crowd.
If you continue through her room and through the doors there is an underwater passageway that will take you to a pool which is almost directly under the entrance to Skull Castle. Climb out of the pool, take the stairs up and you should have no trouble getting back to town!
Good luck!
Wyv
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