Pry is best used for opening jammed doorlocks. Don't use it on chests if you think they may be trapped. It's a rather useless spell; a better one is the 5th level "Disarm Traps", which deactivates trapped locks and chests before opening them.
All the Artifact spells have to be used in the Temple or Wizard's Guild to Enchant or Bless items with qualities from those realms. Pascha just posted a great thread on the benefits of Enchanting and Blessing items. You must first get the Cabalism trait at the Temple to train in Blessing, and the Occultism trait from the Wizard's Guild to train in enchanting. Then you must have an appropriate Artifact spell for the realm you wish to enchant or bless with. A good hint is that the lower the spell level of the Artifact spell, the less useful it is. Artifact of Vines (4th level) just lets you toughen items (not worth it, IMO), whereas Artifact of Spirit (7th level) can be used to add +Hit bonuses to weapons and Regeneration to armor and other wearable items.
-Sazerac
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