1) The ladder problem can be solved with a bit of finagling. You need to look down and back up over the ladder. When you start to fall, look up slightly and your characters should "catch" the ladder. You can then lower yourself down. This takes a lot of practice, and most people when they get their character's HP's up a bit, just take the "SPLAT!" approach.
2) The patch allegedly solves the "crazy-dance" problem when picking up items, but I've never had any trouble picking up an item and I've never yet used the patch. Just make sure you're close enough to the item. Qualifier: I HAVE had considerable trouble picking up items in coffins; for some reason, the stupid coffin is targetable as well! Same goes for spells cast at the skeletons in coffins; sometimes it hits the coffin rather than the skeleton.
3) By default, if you haven't killed a certain type of monster before, your crosshairs won't appear. This is a safety feature that keeps you from killing a useful NPC by mistake. To override it, hold down the CTRL key while pointing at the monster. You should see the crosshairs then. It works the same way for pickpocketing. Once you've killed a certain type of monster (skeleton, bat, etc), all others of their like should be targetable. They'll also be targetable once they've attacked you (i.e., proven themselves to be adversaries).
4) If you create a "Mule" character, remember to remove him or her once every game from the Inn, or the items disappear. This is too corrected by the patch.
5) Rat skull is useless. Chuck it. I have a feeling it may have had some importance originally, but the designers abandoned that.
6) If you're really having trouble with some of the interfaces, put the patch on. Realize that doing so removes some of the official "undocumented features" of the game such as the Gold "cheat" in the Inn or the HP cheat with the Toughen spell. If you're not using these and have no intention of doing so, put on the patch.
Hope this helps!
-Sazerac
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