Think about the Sphinx's questions, they're the ancient history of Gael Serran. Anephas was the figher guy picked by Kerah to defend the lands from the bad guy, the evil Cet-whatever his name is. So Anephas protected, Kerah was like a guardian, etc. Play around with it.
Insanity, probably the most annoying spell, is cured by Exorcism, a high level Spirit spell. As far as I know, there's no protection from it. Of course, if your Priest's insane and your Paladin's Spirit magic isn't high enough, reload the game =)
BTW, I think the Fiend spell "Dementia" makes other people insane.
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