One thing - hold off changing to a warlock until your *second-last class*. It will help you to fill out the level 7 spells of every other school that you have.
My latest restart carried over some gear and 15k from a previous party that played through to freeing D'Soto, so I'm taking a different approach.
I'm using two Elves, mostly for the quick learner trait, but also because I think the animal races are incredibly lame and stupid, Humans are boring, Gnomes are ugly and Pixies are fairies
Male Elf Warrior -> Barbarian (asap) -> Paladin -> Samurai -> Ninja -> Warlock -> Assassin
Female Elf Wizard -> Ranger -> Samurai -> Bard -> Warlock -> Ninja -> Valkyrie (eventually)
I change classes at around 10 - 12 in most cases, unless I'm hanging out for a spell or trait. The warrior should change to barbarian asap, then to paladin after only a few levels. Make sure you set the spawn to hard/infrequent - although you may want to up it to hard/often from time to time
I won't get Fiend magic until the last half of the game, but Sun and Stone are adequate offensive schools, and with Vine and Spirit pretty much all bases are covered. Moon offensive magic seems do be resisted a lot, but the utility spells are good - it can wait though. My paladin could resurrect, and my wizard had Burning Haze and Lightning when they were still in the crypt. Bards suck the way they are implemented - don't waste points on Music (imho).
Join every guild with every character (select a new class, join the guild then cancel the class change). Some of the best stuff needs a high guild level.
Max out Intelligence on every char for the faster xp and skill gains. Having only two characters means that xp comes in three times as fast as a full party, and if you twink a little at the start, and buy the first few levels of magic and weapon skills, then it's not difficult at all.
Have a plan for skills, spells and roles, and focus on them. It's much too easy to piss away hard earned skill points on things that you don't need - music, bows and throwing are good examples.
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