30-40 points is not uncommon for characters late in the game. If you take the example that you run a low fortitude character up to a high level (say 15) then switch him to another class. If you level him all the way to 16, and in the mean time make a few increases to strength and fortitude (say amulets of holding and ankhs). When he finally gets to 16, and out of the 1 HP limit, he will explode for a very big number. I think my best is 31, but a 50-60 wouldn't surprise me.
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