Once the lock is jammed it will never open. Save before hand and juice your strongest character up with heroic might spells, four or five. After six or eight tries, he should break in. Reload if it jams.
If you complete the vampire's quest she will offer you a choice, one of which is a the key and the other of which is a ring. Break the the lock as above and take the ring IF you have the patch installed.
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