Vanilla IWD2 is entirely possible to complete with less-than-perfect parties. HoF mode is as well, but it is much harder to achieve victory without powergaming in HoF. When I played IWD2, I enjoyed challenging myself to finding the best combinations of classes, stats, and races to achieve the most power possible, even though it wasn't really necessary. Truly powergamed characters aren't NEEDED unless you are otherwise limiting yourself, like playing through with only two characters.
Unique combinations are pretty fun to fool around with, if you like. One of my favorite runs through IWD2 was a duo of a drow monk and a human cleric of lathander. The monk had enough magic resist and armor to tank as many enemies as he wanted, while the cleric could nuke them without worrying about his health, heal him, or melee beside him. I've also done theme parties, my favorite of those being the all-paladin party (two paladin/fighters, two paladin/clerics, a paladin/mage and a paladin/sorcerer).
If I were to start a roleplaying party now, I'd go for the standard BGII-type spread. A paladin, a fighter, maybe a rogue/mage, a sorcerer, a cleric, and a ranger.
If I were to make a powergamed party, I'd go for the bare minimum of melee capability (I find it overkill), using only fighter/cleric and a ridiculously multiclassed deep gnome monk as tanks, while filling the rest of the slots with variations of a mage and three sorcerers. Before my disc got corrupted, I actually had a very nice powergamed party going, where my multiclass plan allowed for all 6 members to melee in early parts of the game, but evolve into devastating spellcasters as I progressed.
Still, as Raffin and Xander said, its really up to your preferenc, playstyle, and prowess as to what type of party you'll want to play.
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