Yes it does. And I should know, because I'm a Half-Orc. And everyone knows that Half-Orcs are big. In every department. [img]tongue.gif[/img] But let's stick to the game, there are other places to discuss this kind of thing.
If your off-hand weapon isn't a shortsword or dagger, you
do get additional penalties. -4 to hit for each hand instead of -2, if I'm not mistaken.