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You definitely want your main tanks hitting Melissan as hard as you can at all times, avoid getting them distracted by her summons. You can spend a lot of energy killing the slayer shadows and various denizens of the abyss and she'll just keep bringing out more of them.
If you can get a planetar, two skeles, and two mordies, you should be able to keep Melissan's summons attention long enough to hit her.
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\"Though we name the things we know, we do not necessarily know the things we name.\" -Homer W. Smith
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