Personally, as a first time through, I think I would hold off on Ascension. Just save the game before all major battles. Then once you go through the normal game, load Ascension, go back to the point recommended by Ascension and play the end again with Ascension. I admit that I haven't played with Ascension active prior to that "recommended point", so I don't know what/if I missed anything, but I am enjoying finishing up Ascension and knowing how it compares with the original script.
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