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What order did you install SP2 in? That is, before or afteer your games?
The recommended install order for least problems is: format, install XP, install SP2, install mobo drivers, install graphics drivers, install other drivers as needed, install games. Doing it any other way will almost certainly cause obscure problems, even though MS - to my knowledge - deny this.
But, to cover all bases, try in this order:
1) Reinstall the game.
2) Find better drivers for your mouse
3) Try a different mouse
4) Reinstall Windows XP SP2, in the order I mentioned above.
If it does happen in other programs, skip step 1.
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