You has de bugs. If'n I's be you, I be reinstallin', or at least reloadin'.
The problem most likely lies in your DIALOG.TLK file. That would explain both bugs, since the TLK file is what determines what everyone in the game has to say, and also the lethargic Vampires--as soon as you enter the lair, one of them (Meredath?) says something like "You are foolish to face my mistress, ," or something like that, and then they all go hostile. If that script cannot fire due to corrupted data, a lair full of stoned-out Undead might follow.
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Volothamp's Comeuppance
Everything you ever needed to know about the entire Baldur's Gate series......except spoilers.
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