There are several hints as to the involvement ofthe Twisted Rune in other quests.
SPOILERS (including ToB spoiler)
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A couple come to mind:
1. If, after busting up Rejek's cosmetic surgery operation in the Bridge District, you initiate dialogue with the right merchant in Umar Hills using the right password but then reveal that you're not the person he should be talking to, he threatens you with the Rune before running off.
2. A conversation which you can have with a mercenary wizard about half-way through ToB shows that Balthazar is involved with the Rune as well).
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Do not meddle in the affairs of wizards, for they are subtle and quick to anger.
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