Soloing or not I always do the same.
First I do the easy quests without/little fighting involved. (Skinner murders,Slavers,Circus tent...)
Then I do more difficult quests. Those are usually Stringhold quests.
I usually do all the quests in Chapter 2 except the Twisted Rune and both Dragons.(Sometimes Kangaxx) It depends on my level.
Then to Chapter 3 and smooth sailing. In Chapter Six i do
Major dungeon ToB spoiler:
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first two levels of Watcher`s Keep then I go after the two bosses.
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