This sounds like a reinstall issue to me. Either the area file for at least one map district is corrupted, or the help file (the file that contains those little helpful hints displayed in the "Loading Area" screens) is corrupted.
Had you been playing this game for a while before this became a problem?
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Volothamp's Comeuppance
Everything you ever needed to know about the entire Baldur's Gate series......except spoilers.
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