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Originally posted by Raistlin Majere:
just to clarify, the twisted rune has nothing to do with any quest. it might have had, if the makers had had more time...rumors are, that it was going to be one of the biggest, if not the biggest quest, aside from the main quest. You do get a sweet staff from the encounter, and the encounter is moderately challenging, at least for the first time. Calsiumus has already stated that you need a rogue stone to pass through the door in the bridge district, so i wont have to tell you that 
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Spoilers about Bridge District
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There are some Rune Assassins in the basement of the murderer. It's a very tenuous connection and doesn't lead you to the twisted rune, but it is there nonetheless [img]smile.gif[/img]