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It is very smart while soloing to avoid difficult enemies in the beginning. Therefore I advise you/your wife to do quests like The Unseeying Eye, the Windspear Hills and such later on in the game.
Possible quests that are rather easy, or easier in each case, are the de'Arnise Hold, and the Temple Ruins. Of course, there are some enemies there that can indeed pose a threat, but they are quite doable once you've done a couple of minor quests in Athkatla (like the Skinner Murders, the Graveyard minor quests (Wellyn, The Paladin and the Orphan for instance).

Good luck! Don't take my post as a guidline, and try to found out most of the things yourself!