[Bozos of Bones]

Depends on the program. Some really don't give a rat's ass about that it says in the registry, and you can run them off a banana if you find a way to plug a banana to your computer and use it as storage. Others require their registry paths to stay the same, meaning they may not change their folder, let alone their partition, without registry editing. Then there are those programs that are just idiotic and stupid, and will not for the love of god be installed or ran from anything other than C.