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Running those browsers will make you less prone to further infection in future, and will avoid any spywares which have installed themselves into IE. However, you have to use IE occasioanly, either due to dimwitted webmasters who dont know how to author sites properly, or a site which uses an IE-only feature like activeX.
Also, not all spywares infest the browser, a keylogger for instance, will infect the system itself and dosen't depend on the browser after isntallation. So you want to remove any and all spywares.
Use spybotSD, use adaware, use the M$antispyware beta, and your favorite virus scanner - IIRC, the kaspersky free online scan is the current best available - and if you still have problems after running those in safe mode with windows restore off, then we pull out the big gun, a program known as 'Hijack This'. But that ones a weapon of last resort.
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