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No, I think curses override beneficial effects, so Kiel's Helmet wouldn't take care of the negative effects of the sword.
And to answer the original question, no, don't equip the sword on Minsc. As others already point out, the positive effects (+3) don't weigh up to the negative ones. Especially not since you can find a non-cursed Two Handed Sword +3 within the Tower.
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