First, go to www.trendmicro.com and do an on-line scan. That will remove the viri.
Second, there is a keymapper or something like that in Windows. Someone may have mapped "click" to be "click-F1" or something like that. The fact that the notepad icon file has disappeared is curious... do you mean that it just doesn't show up? That may mean time for a Windows repair install.
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