I think the game becomes more intruiging and satisfying when you impose your own roleplaying restrictions on behavior according to what would be most 'realistic' (i.e., plausible within a fantasy universe containing magic and monsters, that is) for your characters' alignments and bios. IMO definitely much more fun to approach the game that way. For good aligned parties that means not killing off an NPC to split up a pair, either by attack (that is out of character for a predominantly good aligned party), or sending one off to fight a bear barefisted (implausible). If you had an evil character do it in a mixed alignment party, the good characters would leave. And Ajantis would probably attack the killers.
In the case of Khalid and Jaheira, from a strict roleplaying perspective you would not remove one by using the method of placing one in a house. Despite their occasional bickering they there is no way they would split up. If you want to 'lose' either Khalid or Jaheira, since they are both fighters you could however keep the one in question on the front line (properly equipped)placed on a script, and wait until that one meets his or her demise.
Pretty much the same roleplaying constraint applies for Minsc and Dyna. If you read Minsc's bio there is no way he would accept being separated from her. Protecting Dyna is his 'dejemma', a rite of passage in his warrior society by which he becomes a man. However, if you set Minsc in berserking mode and he attacks the party, you could reasonably kill him in self-defense. It's a bit of a stretch, but I guess you could set Dyna on an aggressive mage script and wait for her to fall.
Xzar and Montaron are a different story, of course. They're evil, and neither is Lawful. It is much more plausible that either one could kill the other at any given time (especially Monty slipping a blade into Xzar's back). Or that one might leave the party via the 'remove in house' method. In my current 'evil' game my main character is a necromancer who now has 21 charisma with the tome and Algy's cloak. Xzar is obediently waiting in the house next to the Thunderhammer smithy. I mean, it would be more realistic for Xzar to taken off. But since that option doesn't exist and it is plausible that he would leave, and the only way to do it is put him in a house by himself, then so be it. (I guess you could RP it that Xzar or Monty simply happened to leave the party in a particular dwelling and from there on out as far as you know they split but you have no reason to return there are you could really give a shit what happened to them.)
Eldoth and Skie I havn't used yet. But judging from her bio it would seem tha Skie is hopelessly enamored of Eldoth, and likely wouldn't accept a breakup.
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