As for... sadistic/weird usage of spells...
Any Hold/Stun spell + Darts of Wounding.
"Can you feel it? Your lifeforce ebbing away as the sensation of hopelessness overwhelms you. Don't worry... death will come for you... eventually."
Feeblemind + Punch
You ain't seen nothing yet till you have seen your Mage PUNCH a Dragon unconsicious.
Any Fear spell + Melf's Acid Arrows
"Run fool! Run while the very skin on your body melts away into nothingness. Run all you want, but know that in the end... it is just futile to avoid the fate that I have cursed upon you."
Maze/Imprison + Trap-Based Spells
After caging somebody, lay the zone with multiple castings of Trap-Based Spells( Skull Traps, Symbols, Delayed Blast Fireball, etc...) then free them.
"I'M FREEEEAIYEEEE!!!!"
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These are just some examples. When you play as a Wizard multiple times through the game, you tend to formulate all kinds of whacked up combinations to amuse yourself and torture your enemies.