Help........
I'm in the planar sphere everytime I try to go to the navigation room to encounter Lavok; get screen that says saving game, then the screen that says loading area, then game crashes, get thrown out of game, and computer locks up,
3/4 of screen blacked out, have to use Ctrl, Alt, Del to get computer to respond.

have emptied cache, have reinstalled game several times, have even started game over several times, same thing happens.

I have installed BG2, throne of bhaal, latest patch, then some custom itens that I like, and have used shadowkeeper. I am at a loss as to what to do. Can anyone help me???

Did you install BG2 devices over the complete TOB install? If you install things such as the bonus merchants or script editors for BG2 over a fully installed TOB file it sometimes causes conflicts and corrupts other files.

My advice is to install BG2, THEN install any other misc BG2 files BEFORE installing TOB

I had something like this happen to me. Try going to a area where it needs to load the map, like downstairs in the sphere, and interact with someone and then try going back.