I am at the moment fixing up an old computer of mine, and if everything works out then I will have 2 computers that can play the same games, and I may have an LAN session with my friends. My question: Do mods, such as Ease of Use, work with a multiplayer game? I ask because I have a friend who may play something like a paladin2/cleric, and I was hoping for a 2-handed CS. Thanks!

Yes, it should work.

Thanks for clearing that up!