Can anyone tell me if there are any negative consequences if you fail to meet demands in your thief stronhold. Will it piss them off so that they won't help you?

Sklark, the worst that has happened to me is that if you wait to long to pay you due to the guild you will lose the stronghold, but you can go to Renal and for a hefty sum purchase it back; other than that, I've noticed no other issues.

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To quote the pestering peasant, Neeber, of tradesmeet: "I killed a rabid rabbit! I'm experienced, now!"