Ok, I have a true neutral main character, mincs (true good?), Jaheira (true neutral), Yoshimo (true neutral), and Airie SP? (lawful good). I plan on having a reputaion somewhere between 9 and 12 the whole game, so I can use a variety of NPCs. I plan on dropping some of these people, but I want to keep Minsc at least. I also want Edwin, and maybe Korgan and Keldorn. Would there be a problem here? Would Minsc leave or attack one of my evil characters, even if the reputaion of the party remains somewhat neutral?

And if I happen to start getting my rep too high, what would e the safest way to lower it a point or two?

no don't worry about it. as long as you keep your rep 8-12 there shouldn't be any problem and for losing some reputation. read on...
slight spoiler
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later on in the game you main character can turn into the slayer and everytime u turn to the slayer you lose i think 2 reputation points. The slayer kicks ass and u lose the reputation at the same time.

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Mess with the best Die like the Rest!!

your rep always starts around 9 (good aligment gain bonus, evil has penalty)

**spoil**
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many people say you can use turn slayer to lower rep, which is a good idea. but i heard if you do it over 3 times, you die http://www.tgeweb.com/ironworks/cgi-...iles/smile.gif

I like to do a bit evil things, like if you can free someone, I just charge him 1000 dollars, this way, my rep goes down. also, when it gets too high, I just charm a begger on the street, go to somewhere dark, and kill him, lol this way DRAMATICALLY lowers your rep, becareful

minsc some times DO do some crazy shit to, but it is part of the fun, enjoy http://www.tgeweb.com/ironworks/cgi-...iles/smile.gif

*slight spoil?*
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Also, some of the NPC interactions means that fights can sometimes break out.
I won't say between whom, but it quickly becomes obvious.

teeny spoil?
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There's also a point in the Drow City where you can kill slaves for -1 Rep each

well attack the police who arrests Jan when he tries to sell things to you and you will get -6 http://www.tgeweb.com/ironworks/cgi-...iles/smile.gif

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I've heard that the pen is stronger than the sword ;)

***Party interaction SPOILER***
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You will have some conflict in that party. Minsc and Edwin don't like each other much and Korgan likes to torture Aerie. Remember that Edwin wanted to hire you in BG1 to kill Minsc's former witch, Dynaheir...and now Dynaheir (as you find out early in the game) is dead...so Minsc naturally doesn't like Edwin much. Also, I haven't had Korgan in my party, but I'm told that Aerie will eventually leave if Korgan abuses her too much.