Drunk at the inn near the city gates:

what are you stareing at? never seen a... er... man before?

Best acting- Irenicus, Jahiera when you find khalid. I nearly cried. Most of Jahieras' romance speeches are pretty good. Minsc of course.
Best lines- Minsc when you leave him standing around "Boo needs his exercise lest he bite us all in hard to reach places." Also Edwins conversation with Silvanis in the Copper Coronet after Edwin has read the Nether scroll. Considering Edwins' personality I could imagine all the other characters laughing at him, I sure was. It wasn't so funny when he went postal though.

To get the best speeches you have to play evil. Edwin is fast becoming my favourite speaker. But for example when the boss elf (Eldhan?) makes Viconia swear fealty to the party Korgan chips in with "And if you'll believe that you'll believe anything!" I'm also fond of quoting Edwin's openning speech to the party. "I am Edwin Odeseron, you simians who would prefer a less sylable intensive workout may refer to me as Sir!".

"You must lather your party before venerating froth". - Curdis

Nothing tops the spectator beholder from the Sahauguin City. I was laughing my head off.

I really liked a little exchange between Edwin and Viconia in the Asylum. I had just talked to the girl who saw through the planes and Edwin had a comment to make -

Edwin: A weakness on her part. A superior mind could handle such a gift.
Viconia: Ha! It is a shame we do not have one here.
Edwin: (sigh, it is aggravation like this that will cause me to fireball the entire party in their sleep. Yes, everyone nice and peaceful, then FOOM!!)

Edwin is just hilarious.

Edwin: My name is Edwin Odesseiron. You simians may refer to me merely as "Sir", if you prefer a less...syllable-intensive workout.

Best: lilarcor: hmm taste like chikcen
let's go see what's inside thatone
hey let's go kill that over there
Korgan: (in a very sarcastic tone) hey jaheira, nice stick you got there, why don't you call some squirrels to make the day.
minsc: go for the eyes boo, go for the eyes(especially boo's little scream)

Spectator beholder in Sahuagin City!!! I actually stopped playing, stood up and sit somewhere more comfy than my chair till my laughing came to an end only to start laughing like a madmen at his next line. He is the best bar none.

From a RP perspective I liked what Mincs said when we first entered hell. It's just him, a good, brave and not so intelligent ranger. His tone is fantastic, he actually liked dying on the battle ground helping one of his best friends against evil. I can't remember the exact line but it was something like: "Boo and Minsc were on the way to the glorius fields of Rashamen but we heard you call us and came to help."

I heard this line for the first time yesterday. I'm in the asylum and have to use Minsc in stealth mode because of the lack of a decent thief when he comes out with the classic:

'No-one can see me - but my battle cry may give me away'

Well, its been a long time since i read it, and im translating from spanish, but one of the bests was when I met Firkraag and Minsc said something like:

"We wouldnt be cowards if we leave and return when we have a bigger sword".
Made me laugh over the floor