From what I've learned so far only Aerie and Keldorn can leave without a way of getting them back, to wit:
1. When you've allowed her to leave (in various conversations, etc.), there's no way of getting her back. Likewise, when you screw things up with the Aerie/Haer Dalis fling... (tip - be understanding) http://www.ironworksforum.com/ubb/no...iles/smile.gif
2. When you let Keldorn get back to his family soon as his subquest is over (didn't kill the guy who cuckolded him), he goes for good.
All the others, I think, just go to some default place (e.g. Minsc, Anomen, and Yoshimo at the Copper Coronet,etc.) Others still can be asked to stay where he/she is the moment you let go of them (Cernd, Nalia). One reminder though, beware of leaving a party member behind to stay someplace where enemies abound, they CAN get killed even when they're no longer with your party).
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